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Zakład Biochemii Komórki

     dr hab. Anna Lewińska, prof. UR

     - Kierownik Zakładu /

     Anna Lewińska,

     PhD, DSc, Head of Department

     Tel./Phone:+48178518533,

     pok./room 79, B2, A0

     e-mail: alewinska@o2.pl

 

konsultacje/Consultation hours: wtorek/Tuesday 10:00 - 12:00, pok./room 79, B2, A0

Badania/Research interests: biologia nowotworów/cancer biology, starzenie komórkowe/cellular senescence, toksykologia molekularna/molecular toxicology

see list of publications

 

 

 

 

     mgr inż. Jagoda Adamczyk-Grochala /

     Jagoda Adamczyk-Grochala, BEng, MSc

     Tel./Phone:+48178518533, pok./room 79, B2, A0

     e-mail: ag1jagoda@gmail.com

     konsultacje/Consultation hours: środa/Wednesday

     8:00 – 10:00 pok./room 79, B2, A0

     Badania/Research interests: genomowa niestabilność,

     biotechnologia molekularna/genomic instability, molecular

     biotechnology

 

 

dr Iwona Rzeszutek / Iwona Rzeszutek, PhD

Tel./Phone: +48178518754, pok./room 324, B1, A0

e-mail: iwona.rzeszutek89@gmail.com

konsultacje/Consultation hours: środa/Wednesday 10:30 – 12:30 pok./room 324, B1, A0

Badania/Research interests: genetyka molekularna/molecular genetics

 

 

mgr inż. Magdalena Kulpa-Greszta / Magdalena Kulpa-Greszta, BEng, MSc, PhD student Research, Technical and Administrative Staff.

Tel./Phone. +48 17 851 85 62, pok./room 208, B3, A0

e-mail: magdalena.kulpa90@gmail.com

 

 

Students 2017/2018

Karolina Maziarz (BEng student) - molecular biotechnology

Izabela Bednarska (BEng student) - molecular biotechnology

Ewa Kwaśniewicz (MSc student) - genomic instability, cancer biology

 

Students 2016/2017:

Ewa Kwaśniewicz (BEng student) - genomic instability, cancer biology - Lund University scholarship

Wiktoria Hendzel (BEng student) - molecular toxicology

Karolina Szymura (BEng student) - molecular toxicology

Sofiya Kokhanovska (BEng student) - biotechnology, microbiology

 

 

The list of publications

  1. Lewińska A, Adamczyk-Grochala J, Kwaśniewicz E, Deręgowska A, Semik E, Ząbek T, Wnuk M. Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. Redox Biol. 2018 Apr; 14: 20–34.
  2. Sodagam L, Lewińska A, Wnuk M, Rattan S. Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro. Biogerontology. 2017. Oct;18(5):841-854.
  3. Lewińska A, Adamczyk-Grochala J., Deręgowska A., Wnuk M. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics. 2017. 7(14): 3461-3477.
  4. Lewińska A, Bednarz D, Adamczyk-Grochala J, Wnuk M. Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Redox Biol. 2017 Aug;12:469-482.
  5. Lewińska A, Adamczyk-Grochala J, Kwaśniewicz E, Deręgowska A, Wnuk M. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis. 2017 Jun;22(6):800-815.
  6. Lewińska A, Adamczyk-Grochala J, Kwaśniewicz E, Wnuk M. Downregulation of Methyltransferase Dnmt2 Results in Condition-dependent Telomere Shortening and Senescence or Apoptosis in Mouse Fibroblasts. J Cell Physiol. 2017 Dec;232(12):3714-3726.
  7. Lewińska A, Wnuk M. Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases. Biogerontology. 2017 Apr;18(2):293-299.
  8. Lewińska A, Adamczyk-Grochala J, Kwaśniewicz E, Deręgowska A, Wnuk M. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicol Lett. 2017 Jan 4;265:117-130.
  9. Schwarzbacherová V, Wnuk M, Lewińska A, Potocki L, Żebrowski J, Koziorowski M, Holečková B, Šiviková K, Dianovský J. Evaluation of cytotoxic and genotoxic activity of fungicide formulation Tango® Super in bovine lymphocytes. Environ Pollut. 2017 Jan;220(Pt A):255-263.
  10. Mytych J, Żebrowski J, Lewińska A, Wnuk M. Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells. Mol Neurobiol. 2017 Mar;54(2):1285-1300.
  11.  Adamczyk J, Deręgowska A, Potocki L, Kuna E, Kapłan J, Pabian S, Kwiatkowska A, Lewińska A, Wnuk M. Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts. Arch Microbiol. 2016 Sep;198(7):715-23.
  12. Adamczyk J, Deręgowska A, Skoneczny M, Skoneczna A, Natkańska U, Kwiatkowska A, Rawska E, Potocki L, Kuna E, Panek A, Lewińska A, Wnuk M. Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts. Cell Stress Chaperones. 2016 Sep;21(5):849-64.
  13. Adamczyk J, Deręgowska A, Panek A, Golec E, Lewińska A, Wnuk M. Affected chromosome homeostasis and genomic instability of clonal yeast cultures. Curr Genet. 2016 May;62(2):405-18.
  14. Adamczyk J, Deręgowska A, Skoneczny M, Skoneczna A, Kwiatkowska A, Potocki L, Rawska E, Pabian S, Kapłan J, Lewińska A, Wnuk M. Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts. Oncotarget. 2016 May 24;7(21):29958-76.
  15. Grabowska W, Suszek M, Wnuk M, Lewińska A, Wasiak E, Sikora E, Bielak-Żmijewska A. Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature. Oncotarget. 2016 Apr 12;7(15):19201-13.
  16. Lewińska A, Żebrowski J, Duda M, Górka A, Wnuk M. Fatty Acid Profile and Biological Activities of Linseed and Rapeseed Oils. Molecules. 2015 Dec 21;20(12):22872-80.
  17. Deręgowska A, Adamczyk J, Kwiatkowska A, Gurgul A, Skoneczny M, Skoneczna A, Szmatoła T, Jasielczuk I, Magda M, Rawska E, Pabian S, Panek A, Kapłan J, Lewińska A, Wnuk M. Shifts in rDNA levels act as a genome buffer promoting chromosome homeostasis. Cell Cycle. 2015 Nov 2;14(21):3475-87.
  18. Deręgowska A, Skoneczny M, Adamczyk J, Kwiatkowska A, Rawska E, Skoneczna A, Lewińska A, Wnuk M. Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. Oncotarget. 2015 Oct 13;6(31):30650-63.
  19. Wnuk M, Panek A, Golec E, Magda M, Deręgowska A, Adamczyk J, Lewińska A. Genetic profiling of yeast industrial strains using in situ comparative genomic hybridization (CGH). J Biotechnol. 2015 Sep 20;210:52-6.
  20. Mytych J, Lewińska A, Żebrowski J, Wnuk M. Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes. Biomed Res Int. 2015;2015:304575.
  21. Mytych J, Lewińska A, Żebrowski J, Wnuk M. Nanodiamond-induced increase in ROS and RNS levels activates NF-κB and augments thiol pools in human hepatocytes. Diam Relat Mater. 2015 May 55;95-101.
  22. Lewińska A, Jarosz P, Czech J, Rzeszutek I, Bielak-Żmijewska A, Grabowska W, Wnuk M. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells. Mutat Res Genet Toxicol Environ Mutagen. 2015 Feb;779:23-34.
  23. Grabowska W, Kucharewicz K, Wnuk M, Lewińska A, Suszek M, Przybylska D, Mosieniak G, Sikora E, Bielak-Żmijewska A. Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner. Age (Dordr). 2015 Feb;37(1):9744.
  24. Lewińska A, Wnuk M, Grabowska W, Ząbek T, Semik E, Sikora E, Bielak-Żmijewska A. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015 Mar 18;233(3):227-38.
  25. Wnuk M, Miedziak B, Kułak K, Panek A, Golec E, Deręgowska A, Adamczyk J, Lewińska A. Single-cell analysis of aneuploidy events using yeast whole chromosome painting probes (WCPPs). J Microbiol Methods. 2015 Apr;111:40-9.
  26. Mytych J, Pacyk K, Pępek M, Żebrowski J, Lewińska A, Wnuk M. Nanoparticle-mediated decrease of lamin B1 pools promotes a TRF protein-based adaptive response in cultured cells. Biomaterials. 2015 Jun;53:107-16.
  27. Górska M, Kuban-Jankowska A, Żmijewski MA, Marino Gammazza A, Cappello F, Wnuk M, Gorzynik M, Rzeszutek I, Daca A, Lewińska A, Woźniak M. DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol. Oncotarget. 2015 Jun 20;6(17):15449-63.
  28. Lewińska A, Siwak J, Rzeszutek I, Wnuk M. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Toxicol In Vitro. 2015 Apr;29(3):417-25.
  29. Lewińska A, Chochrek P, Smoląg K, Rawska E, Wnuk M. Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide. Redox Rep. 2015 May;20(3):116-25.
  30. Lewińska A, Adamczyk J, Pająk J, Stokłosa S, Kubiś B, Pastuszek P, Słota E, Wnuk M. Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Sep 1;771:43-52.
  31. Mytych J, Lewińska A, Bielak-Żmijewska A, Grabowska W, Żebrowski J, Wnuk M. Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells. Chem Biol Interact. 2014 Jun 11;220C:51-63.
  32. Lewińska A, Miedziak B, Kułak K, Mołoń M, Wnuk M. Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae. Biogerontology. 2014 Jun;15(3):289-316.
  33. Worek M, Kwiatkowska A, Ciesielska A, Jaworski A, Kapłan J, Miedziak B, Deręgowska A, Lewińska A, Wnuk M. Identification of dermatophyte species using genomic in situ hybridization (GISH). J Microbiol Methods. 2014 May;100:32-41.
  34. Lewińska A, Miedziak B, Wnuk M. Assessment of yeast chromosome XII instability: single chromosome comet assay. Fungal Genet Biol. 2014 Feb;63:9-16.
  35. Dworak N, Wnuk M, Żebrowski J, Bartosz G, Lewińska A. Genotoxic and mutagenic activity of diamond nanoparticles in human peripheral lymphocytes in vitro. Carbon. 2014 Mar;68:763–776.
  36. Bielak-Żmijewska A, Wnuk M, Przybylska D, Grabowska W, Lewińska A, Alster O, Korwek Z, Cmoch A, Myszka A, Pikuła S, Mosieniak G, Sikora E. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta. Biogerontology. 2014 Feb;15(1):47-64.
  37. Potocki L, Lewińska A, Klukowska-Rötzler J, Bielak-Żmijewska A, Grabowska W, Rzeszutek I, Kamińska P, Roga E, Bugno-Poniewierska M, Słota E, Mählmann K, Koch C, Wnuk M. Sarcoid-derived fibroblasts: Links between genomic instability, energy metabolism and senescence. Biochimie. 2014 Feb;97:163-72.
  38. Wnuk M, Lewińska A, Gurgul A, Ząbek T, Potocki T, Oklejewicz B, Bugno-Poniewierska M, Węgrzyn M, Słota E. Changes in DNA methylation patterns and repetitive sequences in blood lymphocytes of aged horses. Age (Dordr). 2014 Feb;36(1):31-48.
  39. Siwak J, Lewińska A, Wnuk M, Bartosz G. Protection of flavonoids against hypochlorite-induced protein modifications. Food Chemistry. 2013 Nov 15;141(2):1227-41.
  40. Potocki L, Lewińska A, Klukowska-Rötzler J, Bugno-Poniewierska M, Koch C, Mählmann K, Janda J, Wnuk M. DNA hypomethylation and oxidative stress-mediated increase in genomic instability in equine sarcoid-derived fibroblasts. Biochimie. 2012 Sep;94(9):2013-24.
  41. Inglot P, Lewińska A, Potocki L, Oklejewicz B, Tabęcka-Łonczyńska A, Koziorowski M, Bugno-Poniewierska M, Bartosz G, Wnuk M. Cadmium-induced changes in genomic DNA-methylation status increase aneuploidy events in a pig Robertsonian translocation model. Mutat. Res. 2012 Sep 18;747(2):182-9.
  42. Wnuk M, Bugno-Poniewierska M, Lewińska A, Oklejewicz B, Ząbek T, Słota E. Aging Process in Chromatin of Animals. Ann. Anim. Sci. 2012 12(3):301–309.
  43. Ząbek T, Czapla P, Wnuk M, Lewińska A, Oklejewicz B, Bartosz G, Słota E. Genetic structure of Hucul and Anglo-Arabian horses at the Tert locus. Ann. Anim. Sci. 2012 12(4): 483–494.
  44. Wnuk M, Bugno-Poniewierska M, Lewinska A, Oklejewicz B, Ząbek T, Bartosz G, Słota E. Age-related changes in genomic stability of horses. Mech Ageing Dev. 2011 May;132(5):257-68.
  45. Lewińska A, Macierzyńska M, Grzelak A, Bartosz G. A genetic analysis of nitric oxide-mediated signaling during chronological aging in the yeast. Biogerontology. 2011 Aug;12(4):309-20.
  46. Wnuk M, Oklejewicz B, Lewińska A, Ząbek T, Bartosz G, Słota E, Bugno-Poniewierska M. PRINS detection of 18S rDNA in pig, red fox and Chinese raccoon dog, and centromere DNA in horse. Hereditas 2010 Dec;147(6):320-4.
  47. Wnuk M, Lewińska A, Oklejewicz B, Bartosz G, Tischner M, Bugno-Poniewierska M. Redox status of equine seminal plasma reflects the pattern and magnitude of DNA damage in sperm cells. Theriogenology. 2010 Dec;74(9):1677-84.
  48. Lewińska A, Wnuk M, Grzelak A, Bartosz G. Nucleolus as an oxidative stress sensor in the yeast Saccharomyces cerevisiae. Redox Rep. 2010;15(2):87-96.
  49. Solarska K, Lewińska A, Karowicz-Bilińska A, Bartosz G. Antioxidant properties of carnitine in vitro. Cell Mol Biol Lett. 2010;15(1):90-7.
  50. Wnuk M, Myszka A, Lewińska A, Tokarz I, Solarska K, Bartosz G. Helicobacter pylori cagA gene polymorphism affects the total antioxidant capacity of human saliva. Helicobacter. 2010 Feb;15(1):53-7.
  51. Wnuk M, Lewińska A, Oklejewicz B, Bugno M, Słota E, Bartosz G. Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro. Mutat Res. 2009 Sep-Oct;679(1-2):18-23.
  52. Wnuk M, Lewińska A, Bugno M, Bartosz G, Słota E. Rapid detection of yeast rRNA genes with primed in situ (PRINS) labeling. FEMS Yeast Res. 2009 Jun;9(4):634-40.
  53. Karowicz-Bilińska A, Płodzidym M, Król J, Lewińska A, Bartosz G. Changes of markers of oxidative stress during menstrual cycle. Redox Rep. 2008;13(5):237-40.
  54. Lewińska A, Bartosz G. A role for yeast glutaredoxin genes in selenite-mediated oxidative stress. Fungal Genet Biol. 2008 Aug; 45(8):1182-7.
  55. Lewińska A, Grzelak A, Bartosz G. Application of a YHB1-GFP reporter to detect nitrosative stress in yeast. Redox Rep. 2008;13(4):161-71.
  56. Wnuk M, Lewińska A, Bugno M, Bartosz G, Słota E. Oxidant-induced decrease of NORs expression in pig lymphocytes can be useful for monitoring the cellular effects of oxidative stress. Mutat Res. 2008 May 31; 653(1-2):124-9.
  57. Lewinska A, Wnuk M, Słota E, Bartosz G. The nitroxide antioxidant Tempol affects metal-induced cyto- and genotoxicity in human lymphocytes in vitro. Mutat Res. 2008 Jan 8; 649: 7-14.
  58. Lewińska A, Wnuk M, Słota E, Bartosz G. Total anti-oxidant capacity of cell culture media. Clin Exp Pharmacol Physiol. 2007 Aug; 34(8):781-6.
  59. Lewińska A, Bartosz G. Protection of yeast lacking the Ure2 protein against the toxicity of heavy metals and hydroperoxides by antioxidants. Free Radic Res. 2007 May; 41(5):580-90.
  60. Lewińska A, Bartosz G. Yeast flavohemoglobin protects against nitrosative stress and controls ferric reductase activity. Redox Rep. 2006;11(5):231-9.
  61. Lewińska A, Biliński T, Bartosz G. Limited effectiveness of antioxidants in the protection of yeast defective in antioxidant proteins. Free Radic Res. 2004 Nov; 38(11):1159-65.

 

Zakład Biochemii Komórki

Wydział Biotechnologii

Uniwersytet Rzeszowski

Pigonia 1,

35-310 Rzeszów

 

Department of Cell Biochemistry

Faculty of  Biotechnology

University of Rzeszow

Pigonia 1,

35-310 Rzeszów

Poland

Nasi partnerzy

Tweety na temat @UR_Rzeszow